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Actos (Pioglitazone)

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Actos is a prescription medicine used to treat the symptoms of type 2 diabetes mellitus. Actos may be used alone or with other medications. Actos is an antidiabetic, thiazolidinediones drug.

Other names for this medication:
Accuglim, Asoformin, Diavista, Euglim, Exerme, Glimiprex, Glimitab, Glita, Glizone, Gluconorm, Glyciphase, Metme, Metride, Nodiab, Pianorm, Pichromet, Pioglar, Pioglit, Pioglitazone, Piokind, Piomed, Pionorm, Pioplus, Piosafe, Piozone, Piozulin, Tribet, Triglycomet, Ziglim, Zogli

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Also known as: Pioglitazone


Actos is an effective drug of the class thiazolidinedione (TZD) with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes mellitus type 2. Actos contains the active ingredient Pioglitazone Hydrochloride. Pioglitazone helps to lower blood glucose levels by increasing the sensitivity of liver, fat, and muscle cells to insulin; enables cells to remove glucose from the blood more effectively, reduces the amount of glucose produced by the liver, and preserves the functioning of the cells in the pancreas that produce insulin. Actos does not cause the body to make more insulin. Therefore, when used alone, it does not cause low blood glucose (hypoglycemia). Actos is used either alone or in combination with other anti-diabetic medications (such as insulin, metformin, or a sulfonylurea such as glyburide). Actos is not taken to treat type 1 diabetes.


The Actos dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Actos to treat
  • other medical conditions you may have, such as congestive heart failure (CHF)*
  • other medications that you’re taking to treat your type 2 diabetes
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

* <em>Actos</em> has a<em> boxed warning</em> for CHF. This is the most serious warning from the FDA. For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

Drug forms and strengths

Actos comes as a tablet that you swallow, and you’ll usually take it once a day. Actos is available in three strengths: 15 mg, 30 mg, and 45 mg.

Dosage for type 2 diabetes

Your doctor will likely have you start taking either a 15-mg or 30-mg dose of Actos once a day. If needed, they may increase the dose by 15 mg for extra control of your blood sugar. The maximum dose of Actos is 45 mg a day.

Your starting dose will depend on if you have other health conditions, such as CHF.* And the dose will be increased over time based on how your body responds.

And in some situations where your body may be very stressed, your doctor may need to change your dose or have you stop taking Actos. So tell your doctor right away if you:

  • have a fever
  • have an infection
  • have had an accident
  • have just had or will have surgery
Never change your dosage of Actos without first talking with your doctor. And before you start taking Actos, be sure to tell them about any medical conditions you have or any other medications that you take. Your doctor will determine what the best dosage is for you.

* Actos has a boxed warning for CHF. This is the most serious warning from the Food and Drug Administration (FDA). For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

What if I miss a dose?

If you miss your dose, wait and take Actos when your next dose is due. Never take two doses in 1 day. If you have questions on when to take your next dose of Actos after you’ve missed a dose, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Actos is meant to be used as a long-term treatment. If you and your doctor determine that Actos is safe and effective for you, you’ll likely take it long term.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actos are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Actos if you are allergic to Actos ingredients. Do not take Actos if you are in a state of diabetic ketoacidosis. Actos is ineffective and possibly harmful in treatment of type 1 diabetes. Do not take Actos if you have congestive heart failure or heart disease, fluid retention, a history of bladder cancer, heart attack, stroke, liver disease, certain eye problems (macular edema), or polycystic ovary syndrome. Actos is not to be used in people with blood in their urine when the cause of this is unknown. Avoid drinking alcohol. It lowers blood sugar level and may interfere with your diabetes treatment. Be careful with Actos if you are pregnant, planning to become pregnant, or breastfeeding. Do not use Actos in treatment of children under 18 years old. Actos may increase the risk of bone fracture in women (usually in the upper arm, hand, or foot). Actos can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Do not take Actos for longer than recommended. Taking Actos for more than 1 year may increase your risk of developing bladder cancer.

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Histamine, released from mast cells and basophils in response to allergen exposure, is a critical mediator in the allergic response. However, it is necessary to perform careful follow-up of CBC patients with unilateral commissural calcium. Transcutaneous intrafold injection for unilateral vocal fold paralysis: functional results. The carbohydrate-binding specificity and molecular modelling of Canavalia maritima and Dioclea grandiflora lectins. Acute renal failure and ureteral leak after open surgery aortoiliac aneurysm repair. The lexical bias effect (LBE) is the tendency for phonological substitution errors to result in existing words (rather than nonwords) at a rate higher than would be predicted by chance. These changes correlate to IOP exposure and may be the result of specific changes induced by the experimental intervention. No foci of necrosis were found and there was no evidence of lymphocyte depletion. Ten of these reaches were in the Upper Tongue River watershed, which has a history of management including timber harvest, tie floating, and road construction.

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Deviations in the X, Y and Z-axis were measured in 10 patients treated with hypofractionated radiotherapy. Relationship between avian and mammalian anti-Mulllerian hormones. Circulating CgA concentrations were also measured in 39 out of the 42 patients. Differential agonistic behavior in mice selected for brain weight. Evaluation of a new benzodiazepine, flunitrazepam (RO 5-4200) as an anaesthetic induction agent. Intra-amniotic injection of Renografin followed by a single-slice computed tomographic scan at the level of the umbilicus is described. Communitywide public education programs in conjunction with targeted interventions for at-risk populations are necessary to produce meaningful improvements in the awareness of stroke and heart attack risk factors and warning signs among Michigan adults. A five-session group intervention instructs participants how to change health behaviors.

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It remains unclear whether young normal BMD reference values specific to an American population can be validly used for T-score calculation in Europeans. In these studies we conclude that lateral ventricular administration of NPY acts to increase systemic MAP and HR and the response is mediated by an increase in sympathetic tone to the heart and especially the splanchnic and skeletal muscle vasculature. The optimal EDTMP concentrations, giving highest tumor-to-liver ratios of enrichment, were between 1 and 10 mM for 100 microL injected volume for the animal model used in this experiment. Effective therapies for FOP, and possibly for a vast array of more common conditions of heterotopic ossification, will be based on blocking activin-like kinase-2, a critical node in the BMP signaling pathway. Theoretical analyses on displacement and drag force were performed to determine whether the motion of the cell involves membrane rotation (i.e., rolling) or sliding. For these purposes spherical aberration-corrected high-resolution transmission electron microscopy is applied in tandem with the numerical retrieval of the exit-plane wavefunction as obtained from a through-focus series of experimental micrographs. Endothelin-1 enhances corneal fibronectin deposition and promotes corneal epithelial wound healing after photorefractive keratectomy in rabbits. When data obtained during surgical stress were compared to the control situation, we found an increase in the LV filling pressures in both groups, while only the isoflurane group showed an increase in heart rate. Hypoperfusion is associated with a disturbed coupling between brain function, metabolism, and blood flow, and may lead to secondary stimulation of anaerobic metabolism.

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These results suggest that some patients can be cautiously but rapidly switched from one MAO inhibitor to another without prolonged drug-free periods. Clinical studies have shown that intensive rehabilitation training is better than moderate training to recover motoric functions. The average and standard deviation of the auditory evoked response in the cerebral cortex of the conscious rat. from the esophageal branches of the coronary vein to the esophageal varices, and from the gastric branches of the coronary vein to the esophageal varices by way of the gastric intramural venula. However, rather than using unrelated metrics, we need to identify their separate components so that possible links between them and ecosystem functioning can be examined using an agreed-upon language. Production of stable rabbit-mouse heterohybridomas: characterization of a rabbit monoclonal antibody recognizing a 180 kDa human lymphocyte membrane antigen. The size of the resulting swelling was significantly larger in 1) the sites inoculated with viable cells (7.5 x 10(9) CFU) suspended in a medium with arginine (arginine medium) than in those inoculated with killed cells, and in 2) those inoculated with cells suspended in arginine medium than with cells suspended in arginine-free medium. However, further esophageal or bronchial repair is necessary in most cases.

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Angiotensin, ACE-inhibitors and endothelial control of vasomotor tone. This study aimed to refine the volumetric analysis comparing the implant and final breast size as well as the intrinsic association of these two factors with postoperative sensory alteration of the breast. Mangabey patterns in captivity appeared very similar to those reported for mangabeys in the wild. To evaluate the effects of exercise training on the changes induced by endotoxin in arterial pressure, heart rate (HR), blood cells, biochemical factors, plasma nitrite/nitrate, methyl guanidine (MG), proinflammatory cytokines, and pathology of the heart, liver, and lung. Mice fed a high fat diet developed hyperinsulinemia, hyperglycemia and liver steatosis, all features of the human metabolic syndrome. Purification of alpha-mannosidase from jack-bean meal suitable for use as reagent.

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Coherent control of ultrahigh-frequency acoustic resonances in photonic crystal fibers. Because the impact of diuretic use on mortality in acute congestive heart failure (CHF) is not known, we examined the association between drug use, fluid balance, and death among 1,150 patients hospitalized for evaluation and treatment of CHF. Our results are best explained by the assumption that abrupt changes are erroneously bound to continuous changes following the occurrence of the abrupt change. Posture, gait and the ecological relevance of locomotor costs and energy-saving mechanisms in tetrapods. Coronary perforation caused by percutaneous transluminal coronary angioplasty (PTCA) occurs rarely and most often leads to communication to the pericardial space. In this large retrospective series, the type of KIT exon 11 mutation was correlated with the origin of GIST, but not with prognosis or response to imatinib. Muscle degeneration and regeneration were induced by a single subcutaneous injection of a snake toxin, notexin. The patient was a 28-year-old woman who came to us with myasthenia gravis. Comorbidity of epilepsy with cerebrovascular diseases, dementias, mental retardation, attention deficit and hyperactivity disorder, brain tumours, infections of the CNS, migraine, sleep disturbances (obstructive sleep apnoea syndrome), substance abuse and multiple sclerosis is discussed. The effects of oxymatrine on immune-function in BABL/c mice with or without heart allograft were further studied.

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Partial purification and mode of action of an enzyme enhancing the priming activity of gamma-irradiated DNA. Use of the Boomerang catalyst advantage closure device to facilitate complex multistaged percutaneous revascularization procedures for the treatment of critical limb ischemia. This mixed population pattern may underlie the perception of depth discontinuities and transparent surfaces. DAC and PTX caused synergistic growth suppression of RCC, suggesting that DAC could strikingly increase the susceptibility of RCC to PTX and that combination chemotherapy with DAC and PTX might be a novel strategy to improve the clinical response rate of RCC. Effects on neurobehavioral performance of chronic exposure to chemically contaminated well water. The radiographic data were then compared with clinical information, including apnea-hypopnea index (AHI), body mass index, and neck circumference using linear regression. Because hyponatremia can arise in hypervolemic, euvolemic, and hypovolemic states, clinicians may not recognize its presence and cause. Integrase interactor 1 (Ini1/hSNF5/BAF47/SMARCB1), the core subunit of the ATP-dependent chromatin-remodelling complex SWI/SNF, is a cellular interaction partner of the human immunodeficiency virus type 1 (HIV-1) integrase. Using epithelia from Dsg3-/- mice, PV model mice, and their respective control mice, the desmosomal components were immunostained using a post-embedding immunogold labeling method, and their precise localization and the labeling density were statistically analyzed in the desmosomes before the occurrence of acantholysis. Determination of soft grain in flour and food pastes by electrophoretic and immunological methods.

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Compared to healthy subjects, the heroin-dependent subjects had reduced GM volume in the right prefrontal cortex, left supplementary motor cortex and bilateral cingulate cortices. The relationships between the composition of both free smooth surface and approximal plaque and salivary composition and sugar intake assessed from a retrospective 24-hour dietary history were investigated. Although synthesized as a nonselective beta-adrenergic blocking compound, sotalol has emerged as the prototype of the so-called class III antiarrhythmic compounds. Patients with extrahepatic portal vein thrombosis may present from infancy through adulthood with variceal bleeding. Role of poly-L-lysine-coated plates and fetal calf serum concentration in sheep chondroprogenitor cell culturing. Use of large-particle talc for pleurodesis in malignant pleural effusion is safe, and not associated with the development of acute respiratory distress syndrome. The presence of dorsolateral mesoderm appears to enhance this response. The nucleotide sequence of the deletion junction revealed a 19 bp insertion of unknown origin with no evidence of repetitive elements. Accumulating evidences are improving this guideline with some issues. The purpose of this study is to evaluate the effect of dexamethasone on the damaged blood-ocular barrier caused by triolein emulsion, using contrast-enhanced MR imaging.

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Follicular variant of papillary carcinoma arising from lingual thyroid. A retrospective study was conducted between March 1999 and May 2004 to investigate 52 AIS patients of Lenke5 and Lenke6. Amidst this background of overall conservation, subtle differences in the components that make up this pathway may have important implications for species-specific defense against key pathogens. Accreditation and the use of outcomes-oriented information systems. Estimates of nitric oxide delivery using a constant flow rate of nitric oxide infused directly into a breathing circuit during controlled mechanical ventilation can be confounded by streaming and tidal propagation of nitric oxide pools. Instead, microbiological monitoring guidelines, such as the periodic testing of aerobic plate counts and mold counts, can be used to verify compliance with the requirements of food quality and food safety management systems.

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Non-overlapping, abutting 20-mer oligonucleotide primers were used to produce a linear product from the circular geminivirus genomic template. His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk. PPARgamma agonists are in clinical use for the treatment of type 2 diabetes. Bone marrow mononuclear cells were cultured by methylcellulose methods for CFU-E and prilosec otc dosage 20 mg BFU-E assays. Severe acid-base disorders accompanying cocaine abuse have been reported but not emphasized in the literature. After adjustments, the total cost of care for contract ADHC patients was found to be significantly higher than the cost for customary care patients, but no significant difference was found between contract ADHC patients and VA-ADHC patients. Isolated interventions such as aspirating subglottic secretions or the use of silver-coated endotracheal tubes have also achieved a reduction in the incidence of VAP. Detection of residual BCR/ABL transcripts in chronic myeloid leukaemia patients in complete remission using the polymerase chain reaction and nested primers.

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Allogeneic recognition of class I molecules: anti-H-2Ld repertoire of H-2b mice includes T cells recognizing mutant class II H-2b (Abm12) molecules. Uncomplicated colonic atresia can be managed by primary repair with little morbidity. The detonation temperature of epoxypropane can provide an experimental datum for analyzing the microscopic mechanism of DDT process. These findings are important for the management of women with diabetes mellitus who initiate late prenatal care. Differences in the behavior of deliquescent zopiclone type of medication additives (sucrose and fructose) are associated with moisture uptake and composition of the deliquesced solution. The PSK stimulation of iodination of both PMN and HL-60 cells depended on incubation time and temperature, and was significantly suppressed by the presence of myeloperoxidase inhibitors.

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The clinical findings in a patient with nonketotic hyperglycinemia. This differential technique exploits the response of abnormal tumor vasculature to inhaled gases and could provide a promising alternative to supplement mainstream cancer imaging modalities such as x-rays and MRI. A morphometric and biochemical investigation of the vesiculation of kidney microvilli. Duration of poverty and child health in the Quebec Longitudinal Study of Child Development: longitudinal analysis of a birth cohort. A growing body of evidence further indicates that chemoattractant GPCRs contribute to tumor growth, invasion, angiogenesis/angiostasis and metastasis. We recommend defining NRS as a report of persistently feeling unrefreshed upon awakening in the presence of a normal sleep duration, occurring in the absence of a sleep disorder. The stress urinary incontinence and age matched control groups were older than the younger control group and had greater parity. Nurses remain the key individuals in providing linkages among elderly and their families and community-based services. Retransplantation of patients with severe posttransplant hepatitis B in the first allograft.

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Emergency relaparotomies following operations ventolin cost usa on the abdominal cavity organs. We have therefore explored the structure of the Drosophila melanogaster Hox protein Ultrabithorax and the impact of its nonhomeodomain regions on DNA binding properties. Resultant recommendations included an integrated strategy consisting of assessment testing, independent study, and simulated NCLEX examinations. Comparison between Gd-DTPA, Gd-EOB-DTPA, and Mn-DPDP in induced HCC in rats: a correlation study of MR imaging, microangiography, and histology. IGF1R depletion also enhanced sensitivity to mTOR inhibition, at least in part due to suppression of rapamycin-induced Akt activation. Work practices and policies of hospital pharmacists preparing antineoplastic agents. These results suggest that both FPs and parents require information about these common paediatric problems.

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Self-reports of physical violence (ages 12-24 years) and theft (ages 12-31 years) were collected across 5 waves. Left ventricular end diastolic pressure and end diastolic segment length in the left circumflex region were increased and aortic pressure was slightly decreased by left anterior descending artery occlusion and hypoxic perfusion, but there was no significant difference between the two conditions. Alternative solutions to difficult wound, skin, ostomy, or incontinence clinical situations will be published. Budwood sections were then slow-cooled at 1 degree C per hour to -3 degree C, held for 24 h at -30 degree C and then rapidly transferred to the vapour phase of liquid nitrogen. To describe the epidemiology, referral system and visual outcomes of eye injuries in children.

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Histomorphology of fracture healing following stabile fixation of lower-leg fractures. Expression of glutamate receptor subunit mRNAs in gonadotropin-releasing hormone neurons during the sexual maturation of the female rat. As the warmer water keeps coming in, the temperature differential decreases, the current starts going back to its original position, and, thus, the suspended solids concentration decreases. Pelvic floor injury is present in the majority of incontinent patients who were eligible for sacral neuromodulation. Crude aqueous extracts of whole telogen mouse skin (TE), anagen skin (AE) or vehicle alone (V) were injected intraperitoneally into mice in which anagen had previously been induced by plucking of telogen hair follicles. The interaction of four putative glutamate antagonists with glutamate and their effects on the toad spinal cord.

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