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Acuren (Amiloride)
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Acuren

Acuren is a new, orally administered, potassium-sparing diuretic with mild natriuretic and diuretic properties. Its primary site of action is the distal tubule of the nephron where it selectively blocks sodium transport, thereby inhibiting sodium-potassium exchange.

Other names for this medication:
Angiozide, Benazeplus, Bifrizide, Bumeftyl, Cibadrex, Coteveten, Dichlotride, Disalunil, Ditenside, Diurace, Diuretidin, Dociteren, Duopril, Eprosartan, Esidrex, Esidrix, Fosinopril, Hexazide, Hypothiazid, Lisiplus, Lisoretic, Lispirl, Maxsoten, Monoplus, Nephral, Pantemon, Renacor, Rethizid, Selokomb, Tiaren, Timolide, Triampur, Triamteril, Turfa, Uniretic, Wytens, Zoprazide

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Also known as: Amiloride

Description

Acuren is a diuretic (water pill) and a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The amiloride component helps minimize potassium loss. Brand name of Acuren is Acuren.

Dosage

Take Acuren by mouth with food. Acuren may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm. If you want to achieve most effective results do not stop taking Acuren suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Do not freeze. Keep container closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acuren are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Acuren if you are allergic to Acuren components or to any ingredient in Acuren or any other sulfonamide (eg, sulfamethoxazole). Be careful with Acuren if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Acuren if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Be careful with Acuren if you have allergies to medicines, foods, or other substances. Be careful with Acuren if you have cirrhosis or liver problems, diabetes, gout, kidney problems or kidney stones, asthma, heart problems, or systemic lupus erythematosus. Be careful with Acuren if you have elevated blood acid, low folic acid levels, or electrolyte problems, or are dehydrated. Be careful with Acuren if you take potassium-sparing diuretics (eg, spironolactone), potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart; cholestyramine or colestipol because they may decrease Acuren 's effectiveness; nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Acuren 's effectiveness and risk of kidney problems may be increased; barbiturates (eg, phenobarbital), certain chemotherapy medicines, corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, narcotic pain medicines (eg, codeine), or medicines for high blood pressure because the risk of their side effects may be increased by Acuren; diazoxide, lithium, or nondepolarizing neuromuscular blockers (eg, pancuronium) because their actions and the risk of their side effects may be increased by Acuren; angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) because the risk of high blood potassium and kidney problems may be increased by Acuren; diabetes medicines (eg, glipizide) or insulin because their effectiveness may be decreased by Acuren. Do not stop taking Acuren suddenly.

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The steroid receptor concentration and the histological morphology of uterine leiomyomata in premenopausal patients undergoing myomectomy therapy with and without a preoperative GnRH analogue, was analysed to evaluate whether the GnRH analogue therapy leads to important hormonal receptor changes, histomorphological changes and a significant shrinkage of the leiomyomata. The presence of intraparenchymal small vessel arteriosclerosis, senile plaques, neurofibrillary tangles and granulovacuolar degeneration was quantified in the brains of autopsided patients from three age groups: 1) 90--99 years old 2) 70--79 years old and 3) 50--59 years old. UbcH10 is known to act as a ubiquitin-conjugating enzyme (E2) for anaphase-promoting complex/cyclosome. Aromatase inhibitor agents in breast cancer: evolving practices in hormonal therapy treatment. Although the endothelium is not required for this response, it is not known whether the endothelium enhances or attenuates shear stress-induced constrictions. Two analogs, beta-dimethylaminopropiophenone (1) and beta-pyrrolidinopropiophenone (3), were further tested for their in vitro effects on the metabolism of Tmolt3 cells. A comparison of ventilatory tests and the response to carbon dioxide rebreathing was made in healthy smokers, nonsmokers, and in subjects with bronchitis.

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