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Alendronate slows calcium loss from bones. It helps to make normal healthy bone and to slow bone loss in people with Paget's disease and osteoporosis. It may be used in others at risk for bone loss. It is more popular than comparable drugs. It is available in generic and brand versions.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

Similar Products:
Levlen, Alprostadil, Hydrea, Adalat, Ticlid, Zolorest, Durize, Reguloc, Fenolid, Cenforce, Glartin, Clobetasol, Deviry,


Alendronate (alendronate) is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

Alendronate is used in women to treat or prevent osteoporosis caused by menopause and in men and women to treat osteoporosis caused by taking steroids.

Alendronate is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.


Take Alendronate Plus D exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Alendronate Plus D tablets are taken once each week. Choose the day of the week that best fits your schedule. Every week, take one Alendronate Plus D tablet on your chosen day.

Take the Alendronate Plus D tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine.

Take the tablet with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking this medicine.

Do not crush, chew, or suck the tablet. Swallow the pill whole.

After taking an Alendronate Plus D tablet, carefully follow these instructions:

Do not lie down or recline for at least 30 minutes after taking Alendronate Plus D. Do not eat or drink anything other than plain water. Do not take any other medicines including vitamins, calcium, or antacids for at least 30 minutes after taking Alendronate Plus D. It may be best to take your other medicines at a different time of the day. Talk with your doctor about the best dosing schedule for your other medicines.

To be sure this medication is helping your condition, your bone mineral density will need to be tested on a regular basis. You may not need to take Alendronate Plus D for longer than 3 to 5 years if you take it for osteoporosis.

If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Alendronate Plus D. You may need to stop using the medicine for a short time.

Alendronate Plus D is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin supplements. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture and heat.

Detailed Alendronate Plus D dosage information


Drink a full glass of milk and seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not make yourself vomit and do not lie down.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alendronate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Alendronate Plus D if you have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus.

Do not take a Alendronate Plus D tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking Alendronate Plus D.

To make sure Alendronate Plus D is safe for you, tell your doctor if you have:

low blood calcium (hypocalcemia); a cancer such as sarcoidosis, leukemia, lymphoma; a vitamin D deficiency; kidney disease; or an ulcer in your stomach or esophagus.

In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Alendronate Plus D, the more likely you are to develop this condition.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre existing dental problem.

Talk with your doctor about the risks and benefits of using this medication.

It is not known whether Alendronate Plus D will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether alendronate and cholecalciferol passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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Cochlear audiometry (electro-cochleography) during the neonatal period. U937 cells do not synthesize leukotrienes after stimulation by calcium ionophore A23187. This article explores the history that lay behind her experience: of sexual relationships with both her master and his son, the births and deaths of two bastard children, and beneath it all, a relationship of antagonism, competition, and intimacy with her mistress. It has been demonstrated that alpha2-adrenoceptor agonists decrease the release and turnover of noradrenaline, and this might prove advantageous in counteracting the neurodegeneration in ischemic brain. The indications of these tests have been restricted, they seen nonetheless always to be of interest in cases of discordance with the clinical history, cutaneous tests and/or measures of specific serum IgE. Dose distributions were optimized with wedges and beam weights to provide a symmetrical dose distribution on the central axis plane. In this article, we summarize the selection criteria, techniques, and outcomes of open mesenteric reconstruction in the endovascular era. Preoperative anthropometric dysmorphology in metopic synostosis.

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Competition and reproduction in mixed infections of pathogenic and non-pathogenic Bacillus spp. While the mechanism through which inter-strand DNA cross-links are removed from mammalian chromosomes is unknown, these lesions are repaired via homologous recombination in lower eukaryotes and bacteria. Genetic association analysis: a primer on how it works, its strengths and its weaknesses. We show that the effect of ICER on the AtT20 cell cycle is correlated to a direct down-regulation of the cyclin A gene promoter by ICER. Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study. To investigate the functional connectivity (FC) pattern within an intrinsic functional organization, including both task-positive (TPN) and task-negative (TNN) networks, in major depressive disorder (MDD), and to examine relationships between the involved FCs and clinical variables. A study of the gram-negative bacterial flora in patients with ankylosing spondylitis.

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Cases with a Robertsonian translocation or pericentric inversion 2 or 9 were not included. The acute effects of oral administration of felodipine 10 mg and nifedipine 10 mg on heart rate, blood pressure, forearm blood flow and hepatic blood flow were studied in nine healthy men. Renal cell carcinoma is the most common recipient of tumor-to-tumor metastasis in malignant tumors. New experimental data are presented that support this hypothesis. It is likely that CA1 gene expression in these cells is regulated by differential transcription and/or mRNA stability. First total syntheses of (-)-macrosphelides J and K and their structural elucidation are described. hSgo2 is concentrated at the inner centromere of unattached kinetochores, but extends toward the kinetochores that are under tension.

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Welcome Bay and Chaguaramas Bay in the northwest peninsula of Trinidad contain large marinas and smaller sections of bathing beaches. Peripheral blood mononuclear cell proliferation in response to liver membrane protein was significantly higher in chronic hepatitis dogs compared to control dogs. Expressions of the polarization surface charge density, the electrostatic potential energy, and the electrostatic interaction including the contribution from the polarization surface charge densities are given. Thioflavin T displays enhanced fluorescence selectively inside anionic micelles and mammalian cells. The detritic fragments and hydroxyapatite crystals were mainly deposited in the pocket of the joint capsule and some of them were embedded beneath the synovial membrane. Which generic health related Quality of Life questionnaire should be used in older inpatients: comparison of the Duke Health Profile and the MOS Short-Form SF-36?. Corrections in the catalogue of oliogonucleotides produced by digestion of Escherichia coli 16S rRNA with T1 RNase. We investigated the effect of beta-glucan on the production of tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory mediator, in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene, is a cytoskeletal protein tightly associated with a large oligomeric complex of sarcolemmal glycoproteins including dystroglycan, which provides a linkage to the extracellular matrix component, laminin.

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High molecular weight aspartic endopeptidase generates a coronaro-constrictory peptide from the beta-chain of hemoglobin. Insulin secretion is regulated by changes in blood glucose, as well as by peptides from the gastrointestinal tract and neurotransmitters that activate the pancreatic islet adenylyl cyclase (e.g., glucagon-like peptide-1) and phospholipase C (PLC) (e.g., acetylcholine) signaling pathways to further potentiate glucose-induced insulin secretion. Our r results raise the possibility that the carcinogenicity of PPs may be due, in part, to epigenetic modulation of growth-regulatory signal transduction pathways. The use of radiolabelling techniques to measure substantivity to, and penetration into, hair of protein hydrolysates. It shows how queuing theory provides managers with insights into the causes for excessive wait times and the relationship between wait times and capacity. Five patients 16 to 42 years old (median age 30 years) received primary radiation therapy for stage III disease. The preconditioned hippocampus accelerates HSP70 heat shock gene expression following transient ischemia in the gerbil. Weddell seals undergo lung collapse during dives below 50 m depth. Suspected adverse reactions to clostridial/pasteurella vaccines in sheep were a dominant feature and important experience was gained both in terms of liaison with the farming press, and in handling large scale incidents involving PML products. Finite-difference time-domain numerical simulations confirm the theoretical prediction and demonstrate that the normalized-to-area transmittance of 10.8 and 14.7 and beaming angle of 2.40 degrees and 2.65 degrees for 442 nm and 633 nm, respectively, are achieved with a single structure, suggesting the potential applications of such structures in optical data storage, nanoscale wavelength multiplexing, directional light sources and emitters.

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For a long time, the mechanisms that underly the formation of tight junctions and the development of apico-basal membrane polarity in epithelial cells have been poorly understood. As described in other SCD proteins, the predicted amino acid sequence of bovine SCD5 includes four transmembrane domains and three conserved histidine motifs. This case study of the left ventricular assist device (LVAD), while demonstrating the interaction of science, industry, politics, and economics in health care, suggests there are three critical points in the life cycle of a new technology. Counts above background were found in the cingulate gyrus, septum, ventral nucleus of the diagonal band, midline thalamic nuclei, habenula, caudate and substantia nigra. The passive method employs a narrowband microphone that is sensitive to the sound from footsteps. The capability of alveolar macrophages to support prolonged RSV replication may have a role in the pulmonary response to RSV infection. Absorbance and fluorescence properties of protochlorophyllide in etiolated bean leaves. An integrated series of programs was written in the C computer language to implement a back propagation algorithm.

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Light microscopic analysis of ground sections indicated that, from day 6 onward, cells morphologically consistent with the osteoblastic phenotype were predominant within the gap between the surgical margin and implant surface. The prion protein (PrP) plays a key role in the disease, with coding polymorphism in both human and mouse influencing disease susceptibility and incubation time, respectively. This results in resistance of the mutant virus strains to the CBAs. One hundred eighty-nine independent episodes from 187 children 2 to 17 years old were studied. The effective delivery of robust multidisciplinary frameworks for the palliation of symptoms of hospitalized dementia patients remains an important clinical goal.

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A bone cancer pain model was made by implantation of sarcoma cells into the intramedullary space of the mouse femur. Using the appropriate summation time, we obtained the cbOEF image with good correlation with qOEF image, which suggests non-invasive cbOEF image can be used for evaluating the degree of misery perfusion in patients with chronic unilateral brain infarction. Long-term follow-up of patients with lichen sclerosus: does it really happen?. Bone cells were subjected to cyclical strains in vitro by computer-controlled stretching of the plastic substrate on which they were cultured, enabling both physiological and pathological strains to be investigated. Eleven of 15 patients with a severe or complicated gram-negative urinary tract infection were cured by treatment with a five day course of tobramycin. The methodology of the search for a candidate gene for hereditary haemochromatosis is described and the results critically evaluated.

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An overview of principles of effective treatment of substance use disorders and their potential application to pregnant cigarette smokers. New classification of idiopathic inflammatory myopathy (IIM) defined three major entities, polymyositis (PM), dermatomyositis (DM) and sporadic inclusion body myositis (s-IBM). Lupus nephritis was also significantly reduced in the drug-treated groups, and this was related to reduced glomerular deposition of IgG. Two infant deaths linked to intussusception without peritonitis. Early-onset infection after hemiarthroplasty of the hip: an algorithm for surgical therapy. Apixaban, an oral potent reversible direct inhibitor of activated factor X, has shown promise in the prevention of venous thromboembolism following major orthopedic surgery. Dysfunction of IRS proteins initially leads to post-prandial hyperglycemia, increased hepatic glucose production, and dysregulated lipid synthesis and is discussed as major pathophysiological mechanism for the development of insulin resistance and type 2 diabetes mellitus.

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Utilization of urea nitrogen for albumin synthesis in the stagnant loop syndrome. We report a general method for incorporation of nanoparticles into polyelectrolyte multilayer (PEM) thin films by utilizing the excess charges and associated counterions present in the PEMs. We suggest that where imaging is indicated in the assessment of vertebral body fracture healing MRI can be used routinely with CT reserved for problematic or inconclusive cases. A significant increase of the activity of all the exoglycosidases in serum and in synovial fluid of the patients with different forms of arthritis was found. Antigens extracted from leprosy bacilli obtained from infected human and armadillo tissues have been examined by immunodiffusion analysis with serum samples from lepromatous patients and with immune sera raised in rabbits. Despite limited feasibility, the initiative provided valuable visibility and branding of the intervention within the community as well as lessons for working with restaurants to improve health. In this review, we describe the different therapeutic approaches that were so far tested in experimental models of MG and discuss their underlying mechanisms of action. In contrast to liver, neither cytochrome nor N-hydroxylation of 2-FAA was detected in the mammary gland of normal and 3-methylcholanthrene-treated rats. Twenty-nine volatile compounds were considered as contributing to the odor of Saint-Nectaire cheese.

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Serum luteinizing hormone (LH) during the ovulation period was unchanged. A computer analysis performed on rat and human promoters of these two transcription factors shows that putative P-responsive elements are present in Krox-20 but not in Sox-10. The effect of a cholinesterase inhibitor on the vitality in Alzheimer disease. There were no statistically significant differences in twenty-fourth hour NACS evaluations, Apgar scores, umbilical arterial blood gas values, delivery times, and maternal blood loss between the groups. This study suggests that preoperative segmental instability may be a criterion determining whether an additional PLIF would be beneficial in the treatment of lumbar DS. This commentary reviews historical origins of these different care standards, explores political factors responsible for their perpetuation, and uses experience at University of Michigan to dramatize the ways in which history, politics, and biomedicine intersect to produce patient care.

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The effect of anesthetizing with a 1:1 combination of tiletamine hydrochloride and zolazepam hydrochloride (TZ) was evaluated in 75 Japanese black bears. The mechanisms linking ischaemia, flow changes, and brachial artery dilatation are unclear, and it is not known how these are affected by arterial disease. The mild haemolysis and the total absence of thrombosis should be related with the rate-regulation of the pump on the arterial tree rate, thus providing a maximal yield. Heart transplantation remains the best therapeutic option for the treatment of end-stage heart failure. We review sources of bias which can affect non-randomized cohort studies of non-specific effects of vaccines on child mortality.

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Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update. The method was successfully applied to in vitro pharmacokinetic-pharmacodynamic studies. We used a Not I restriction trapper to select target DNA fragments from Not I, Eco RV double digests of genomic DNA. Some of these non-proliferating cells were able to re-enter subsequently the mitotic cycle. The clinical utility of a heterologous radioimmunoassay for human prolactin. By 24 h, the number of injured cells had decreased so that no significant difference from control was evident.

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