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Alpertan (Valsartan)
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Alpertan

Alpertan is an angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors. Alpertan belongs to the angiotensin II receptor blocker (ARB) family of drugs.

Other names for this medication:
Alsart, Alsartan, Arovan, Cardival, Codiovan, Combisartan, Cordinate, Corixil, Cotareg, Diovane, Disys, Dosara, Kalpress, Miten, Nisis, Nisisco, Provas, Ramartan, Sarteg, Sarval, Simultan, Starval, Tareg, Teval, Valitazin, Valpresan, Valpress, Valpression, Valsabela, Valsacor, Valsan, Valsaprex, Valsar, Valsartan, Valsartanum, Valtan, Valzaar, Valzek, Valzide, Varexan, Vasaten

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Also known as: Valsartan

Description

Alpertan (valsartan) is an angiotensin II receptor blocker (sometimes called an ARB). Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Alpertan is used to treat high blood pressure (hypertension) in adults and children who are at least 1 year old. Lowering blood pressure may lower your risk of a stroke or heart attack.

Alpertan is also used in adults to treat heart failure and lower your risk of needing to be hospitalized, and to lower your risk of death after a heart attack.

Dosage

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 40 mg orally twice a day Maintenance dose: 80 to 160 mg twice a day. The dose should be increased to the highest dose tolerated by the patient.

Usual Adult Dose for Hypertension:

Initial dose: 80 to 160 mg orally once a day. Maintenance dose: 80 to 320 mg orally once a day

Usual Adult Dose for Myocardial Infarction:

Initial dose: 20 mg orally twice a day Maintenance dose: The initial dosage may be titrated upward within 7 days to 40 mg twice daily, with subsequent titrations to a target maintenance dose of 160 mg twice a day as tolerated by the patient. If symptomatic hypotension or renal dysfunction occurs, consideration should be given to a dosage reduction. Comment: Valsartan may be initiated as early as 12 hours after a myocardial infarction, and may be given with other standard postmyocardial infarction treatment, including thrombolytics, aspirin, beta blockers, and statins.

Usual Pediatric Dose for Hypertension:

6 to 16 years: Initial dose: 1.3 mg/kg once a day (up to 40 mg) Maintenance dose: up to 2.7 mg/kg (up to 160 mg) once a day titrated according to patient response Comments: If the calculated dosage does not correspond to the available tablet strengths, or if children are unable to swallow tablets, the use of a suspension (which can be prepared from the tablets) is recommended. The valsartan dose may need to be increased if the suspension is replaced by a tablet. No data are available in pediatric patients either undergoing dialysis or with a glomerular filtration rate less than 30 mL/min.

Detailed Alpertan dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep your medicine container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alpertan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use this medicine if you are allergic to valsartan or hydrochlorothiazide, or if you have:

decreased urination or are unable to urinate; or an allergy to sulfa drugs.

If you have diabetes, do not use Alpertan HCT together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking Alpertan HCT with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

an electrolyte imbalance (such as low levels of potassium or magnesium, or high levels of calcium in your blood); liver disease; kidney disease; gallstones; lupus; congestive heart failure; gout, or high levels of uric acid in your blood; asthma or allergies; high cholesterol or triglyceride levels; an allergy to penicillin; glaucoma; or if you are on a low-salt diet.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breastfeed while using this medicine.

Alpertan HCT is not approved for use by anyone younger than 18 years old.

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The aim of this study was to investigate the application of a novel magnetic field enhancement technology to peptide delivery across the skin. Results underscore the importance of youth alcohol assessibility. Pathomorphological characteristics of changes in the lungs after pulmonary hemorrhage in tuberculosis. Projections from the hippocampal formation to the medial prefrontal cortex are well known. T-cell DNA methyltransferase expression is regulated in part by the extracellular signal-regulated kinase (ERK) signaling pathway. A separate analysis of BMD in both sexes revealed that females presented a more important bone loss in both cortical and trabecular bone than males. To examine the role of overweight and obesity on the glycaemic response to foods across the whole population. Mucin-like glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi. From this meta-analysis and a review of the literature, we show that ependymomas in children exhibit a different genomic profile to those in adults and reinforce the evidence that ependymomas from different locations within the central nervous system (CNS) are distinguishable at a genomic level.

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Stimulatory effect of some therapeutic drugs used for improving cerebral insufficiency on gastric acid secretion in rats. Although several risk factors for cognitive decline have been identified, much less is known about factors that predict maintenance of cognitive function in advanced age. AR binds at a distinct androgen-response element (ARE) in the Cdc6 promoter that is functionally required for androgen-dependent Cdc6 transcription. Asphyxia caused permanent CVI in 34 children, of whom 16 were preterm, 17 were term and one lost vision later in life. During the winter months, the children tended to suffer from deeper burns. SMYM-PRGP was wild-type for known mutation sites in the BRAF and NRAS genes, and showed focal amplification of the human telomerase reverse transcriptase and cyclin D1 genes as well as the fibroblast growth factor-3 and fibroblast growth factor-4 genes. Highly specific images of 127I-MIBG biodistribution were mapped within the tumor after in vivo administration of can i drink alcohol with rulide the drug and sample processing with cryotechniques (high-speed freezing and cryo-embedding), which prevent MIBG diffusion from original sites of uptake. The aim of this paper, written with the clinician in mind, is to summarize some of the most prominent controversies that may have importance in usual clinical practice. Conversely, PNC prevalence was reduced experimentally by over expressing an antimetastatic protein in breast cancer cells.

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Effects of hypothalamic stimulation on pituitary-adrenocortical activity in conscious unrestrained pigeons. ICP gradients between hemispheres developed as the pressure was increased to in excess of 50 mm Hg. Wavelet-based analysis of surface mechanomyographic signals from subjects with differences in myosin heavy chain isoform content. It is concluded that osteodystrophy recognizes a number of factors as may be hypocalcemia due to a decrease in the production of 1,25-cholecalciferol, an increase in the parathyroid hormone and the deposit of aluminum, coming mainly from water, in the trabeculae which interfere with the incorporation of calcium in the formation of new bone. Depending on population densities and agricultural intensities, intake fractions can vary by eight orders of magnitudes, and even limited indoor emissions can lead to intakes comparable to those from outdoor emissions. A higher score on Item 9 of the PHQ-9 indicates a greater likelihood that the patient is suicidal. We investigated the effects of inhibiting GSK-3 on lipopolysaccharide (LPS)-induced acute renal failure, nuclear factor-kappaB (NF-kappaB), inflammation and apoptosis. Cytotoxic drugs such as cyclophosphamide and azathioprine suppress the immune response by inhibiting protein (ie, antibody) synthesis, DNA replication, and cell division.

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