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Alrest (Clonazepam)
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Alrest

Alrest is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Alrest was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Almac, Alrest, Anxrea, Azpax, Calmnir, Cleps, Cloam, Clonatrac, Clonax, Clonaxyl, Cloneepam, Clonopam, Clozep, Clozipam, Convaclon, Deptune, Eminaz, Epcon, Epitril, Escimax, Esitor, Ezinite, Lonazep, Lozep, Melzap, Nazee, Nexclo, Norep, Nozim, Nupam, Sezolep, Somnotril, Xitzen, Zepam

Similar Products:
Cialis, Levaquin, Abhigra, Dilantin, Suprax, Diovan, Minipress, Formador, Trozocina, Trimezol, Klariger, Norvasc,

Also known as: Clonazepam

Description

Alrest is a benzodiazepine medication that was initially primarily used for the treatment of seizures occurring in epilepsy and for anxiety, specifically anxiety that occurs in panic disorder. Alrest is available in tablet form (0.5 mg, 1 mg, 2 mg) and as disintegrating wafers that are taken orally.

While Alrest is generally prescribed for the treatment of anxiety disorders, such as panic disorder, and seizure control, it is intended as a short-term treatment protocol as opposed to a long-term treatment solution due to issues with tolerance (see below). In addition to treating anxiety and seizures, Alrest has also been used in the treatment of:

chizophrenia, especially when the individual with schizophrenia has a restless or irritable component and is not responding to antipsychotic medications.

The manic phase of bipolar disorder or for restlessness associated with depression in bipolar disorder.

Tic disorders, such as Tourette's syndrome, by acting as a muscle relaxant and producing sedation.

Restless leg syndrome.

Withdrawal from alcohol or treatment for other substance abuse or addiction issues.

Alrest has a relatively slow onset of action (it takes a while for the drug to begin working) and a half-life of between 10 and 50 hours. As it has a relatively slow onset of action and is a longer-acting benzodiazepine, Alrest is more suited for the treatment of anxiety, seizures, and other similar disorders as opposed to being a useful sleep aid, even though it is sometimes prescribed for that purpose. Sleep aids need to work quickly, whereas with Alrest, a person takes the drug early in the day and doesn't have to worry about monitoring for signs of a seizure or panic attack as it stays in the system a relatively long time. Its effects last longer than those of shorter-acting benzodiazepines, such as Xanax.

As it is a Schedule IV controlled substance, Alrest can only be legally acquired with a prescription from a physician.

Dosage

Take this medication by mouth as directed by your doctor, usually 2 or 3 times daily.

Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose, take it more often, or take it for a longer time than directed.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

Overdose

Treatment after Overdose. If a person accidentally overdoses on Xanax, Valium, or Alrest due to interactions with prescription medications, this is unlikely a sign of addiction or abuse. However, if the overdose was the result of benzodiazepine abuse of any kind, help is needed.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Alrest Wafer dosage information

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Coarticulation effects of post-consonantal vowels on the short-term recall of pre-consonantal vowels. Reduced PDEF expression increases invasion and expression of mesenchymal genes in prostate cancer cells. The molecular biology study with reverse transcriptase polymerase chain reaction (RT- PCR) and sequencing showed that the ends of exons 25, 31, and 45 in the COL1A1 gene were fused with PDGFB. Study of efficiency of suppression of DNA-ligase mutations of phage T4B by different rII mutations. The histological findings four and six weeks after transplantation showed the presence of prominent NSCs in the right periventricular region. It is hypothesized that autoregulation of the blood supply from the arterioles to the capillary bed can be modeled by allowing the flow resistance at the interface of the artery and capillary compartments in the model to be a function of pressure rather than a constant. Integrated systems of prehospital management and clinical pathways are necessary to reduce this treatment gap. During sporulation of Bacillus subtilis 168 there is an increase in activity of alkaline phosphatase in the presence of Pi.

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This report documents the dynamics of eardrum pathology, hearing acuity, and eustachian tube function during 25 years after treatment of bilateral secretory otitis media. The authors report on a three-and-a-half-year follow-up study of 55 young adult and adolescent treatment-refractory inpatients after long-term hospitalization. Changes in pulmonary function following radiotherapy of breast cancer. To investigate reports that the biosynthesis of nitric oxide (NO) is increased in the colonic mucosa of patients with active ulcerative colitis (UC), which suggests that serum NOx levels may be an important indicator of UC activity. The apparent localization of the major amino acid transport to the ileum as reported by others may be an artifact reflecting the inclusion of an undetermined amount of non-absorbing muscle mass in the calculation of intestinal transport. We report the case of a pulmonary infection with Strongyloides stercoralis in a 61-year-old male with a history of a long-term administration of corticosteroids. Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents.

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We discovered that the plasma levels of Transforming growth factor beta-1 rapidly increased to significantly higher levels in the first two weeks post-injury and fell thereafter, in patients who healed with good quality scars post-burn. In a separate cohort, hypothalamic-pituitary-adrenal-axis activation was measured via plasma corticosterone levels following either a single male-exposure or separation episode. Functional gastrointestinal disorders are highly prevalent in out-patients with IBD. Glycoside analogs of beta-galactosylceramide, a novel class of small molecule antiviral agents that inhibit HIV-1 entry. Conjugated linoleic acid (CLA) is reported to have anti-cancer activity, based on animal and in vitro studies. This approach will permit us to work on wide operating fields with large organs, as the kidney, minimizing skin incisions. The use of antibiotics in food-producing animals has generated considerable interest because the widespread administration of these drugs may lead to the development of resistant human pathogens. The integration of targeted treatments with conventional cytotoxic drugs has expanded the treatment of metastatic disease resulting in incremental survival gains. The study results must be interpreted cautiously even after adjustment by age, gender and morbidity. The article is about nurses and physicians who worked together in a continuous quality improvement process to find a collaborative method to reduce the occurrence, severity, duration, and devastating outcomes of acute delirium.

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A study of cyst fluid and plasma carcinoembryonic antigen in patients with cystic ovarian neoplasms. Nitrogen narcosis and rat behavior on fixed-ratio and differential-reinforcement-of-low-rate schedules. To determine the source of the synthesized apoE, we performed simultaneous in situ hybridization and immunocytochemistry on human and rabbit atherosclerotic tissue. An improved understanding of aortic valvar anatomy could assist in further developing surgical repair of the valve. An influenza pandemic exercise in a major urban setting, Part I: Hospital health systems lessons learned and implications for future planning.

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The proportion of variance accounted for by the changes in cognitive coping and negative thinking was somewhat higher. Study of efficiency of therapeutic and preventive anaferon (pediatric formulation) in mice with influenza infection. In order to learn more about the involvement of this enzyme in this process, in situ-hybridization as well as immunolocalization were performed in parallel. Presynaptic glutamate release elicits brief waves of membrane depolarization in neurons by activating AMPA receptors. Most PHA binding sites on PBL of the three species were shown on the surfaces of non-B lymphocytes. The potential array of presenting symptoms often makes the diagnosis complex, although the condition is predominantly assessed by the urologist as a consequence of incontinence surgery. We aimed to develop a more direct and faster method to detect IRAP. This mechanism, rather than the transcriptional activation, was the primary response and is adequate to explain the ascorbate-induced increase in collagen synthesis. A retrospective audit of case notes of patients for 12 consecutive months in 2007. Skin irritation and sensitization: mechanisms and new approaches for risk assessment.

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Here we show by electro-mobility shift assay (EMSA) and immuno-staining that constitutive NF-kappaB activation is present in various malignant glioma cell lines as well as in primary cultures derived from tumor tissue. The protein is a mononuclear non-haem iron(ii)-dependent dioxygenase that converts HEP to HMP and formate. However, there is evidence that subtle neurological impairment remains common in early treated subjects and in the last 3 years there have been a number of reports of overt neurological impairment with white matter abnormalities on MRI. A detector temperature investigation demonstrated that, for the efficient transfer of high-molecular-weight compounds from the column to the detector, the interface to the detector must be heated. Predictors of the intensity of symptoms in a cluster in patients with breast cancer. A low-grade malignancy tumor, small sized and completely resected leads to a good prognosis.

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A baboon (Papio anubis) that had been given opiate compounds through an indwelling catheter developed mucopurulent airsacculitis. Analysis of casualties referred to Army physical medicine services during the Persian Gulf conflict. Effect of ethanol, temperature, and gas flow rate on volatile release from aqueous solutions under dynamic headspace dilution conditions. However, over the course of smoking, proximal cues may not be the only stimuli to become strongly associated with smoking. This systematic assessment illustrated the different clinical character of cHSP and pHSP with respect to the cognitive profiles. It was initially responsive to temozolomide, cyclophosphamide, etoposide, and carboplatin, perhaps predicted by combined loss of heterozygosity at 1p and 19q.

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