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Simvastatin

Simvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins." It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks.

Other names for this medication:
Actalipid, Docsimvasta, Dosavastatin, Lipex, Lipinorm, Lodales, Normotherin, Simbastatin, Simgal, Simvastatin, Simvastatina, Simvastatinum, Simvofix, Sinvacor, Sivastin, Statinal, Vasilip, Zocord, Zorced, Zorstat, Zosta, Zostin, Zostine, Zovast, Zovastin, Zovatin, Zurocid

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Description

Simvastatin (simvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."

Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Simvastatin is used in adults and children who are at least 10 years old.

Dosage

Take Simvastatin exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects.

Simvastatin is usually taken at bedtime or with an evening meal. If you take this medicine more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results.

While using Simvastatin, you may need frequent blood tests at your doctor's office.

You may need to take Simvastatin on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.

Simvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Simvastatin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Simvastatin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Simvastatin if you are allergic to simvastatin, if you are pregnant or breast-feeding, or if you have active liver disease.

The following drugs can increase your risk of serious muscle problems if you take them together with Simvastatin. These drugs should not be used while you are taking Simvastatin:

cyclosporine; danazol; gemfibrozil; nefazodone; an antibiotic - clarithromycin, erythromycin, telithromycin; antifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole; hepatitis C medications - boceprevir, telaprevir; or HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Before you start taking Simvastatin, tell your doctor if you are already using any of these other medicines:

lomitapide; or heart medication - amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil.

To make sure Simvastatin is safe for you, tell your doctor if you have:

history of liver disease; history of kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily.

Simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take Simvastatin if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine.

Simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Simvastatin.

Simvastatin pregnancy and breastfeeding warnings (more detail)

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Accuracy in the target determination is required and a complete stereoangiography is necessary. To find out the prevalence of chronic suppurative otitis media among school children studying in urban private schools of Nepal. A cochlear implant vocoder was used to evaluate relative contributions of spectral and binaural temporal fine-structure cues to speech intelligibility. Ingroup ambivalence and experienced discomfort: the moderating roles of affective versus cognitive attitudinal basis, group identification, as mediated by negative beliefs about the ingroup. Our findings are the first to show that the Trk A receptor uses a classic G protein-coupled receptor-signaling pathway to promote differentiation of PC12 cells. These results are consistent with selection for increased reproduction during range expansion. Twenty-one experimental defects received bioactive glass implantation (test group), while 17 control defects were treated with a flap procedure only (control group). We propose an alternative to univariate statistics for identifying population differences in functional connectivity.

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Exactly how the brain accomplishes this feat and, in particular, the precise temporal dynamics of this attentional deployment are as yet unknown. Since that time she had 6 episodes lasting 6-8 weeks with the average interval of 1 year and 4 months. A 48-year-old male patient with acute occlusion (5 cm) of a leg artery was treated with the rheolytic thrombectomy (RT). It is probably also effective in other hyper-tumor necrosis factor (TNF) states. Multimode nonclassical states of light are an essential resource in quantum computation with continuous variables, for example, in cluster state computation. Ethical considerations in the management of asylum seekers on hunger strike. This study showed a significant increase in the distance from the popliteal artery to the posterior cruciate ligament through arthroscopic limited posterior capsular release during arthroscopic transtibial posterior cruciate ligament reconstruction.

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These results suggest that exposure to a high concentration of lambda-CO activates the mitochondrial-mediated apoptotic pathway and cell cycle arrest by generation of ROS. CHEMICAL AND CHEMOTHERAPEUTICAL STUDIES ON THE FURAN DERIVATIVES. Effects of recombinant adenovirus encoding human apM1 gene on proliferation and nitric oxide synthase activity in human umbilical vein endothelial cells. To demonstrate an important limitation of empirical tests of the proposition that medical care has contributed to long-term declines in mortality. With gradual improvement of consciousness, she showed bilateral abducens nerve palsy, quadriparesis and cervical instability. Chi-squared tests examined the relationships between the self-assessed masticatory ability and the background factors and oral conditions. Because the median lethal doses of Grafton putty (0.00469 mL/g) and glycerol (0.00442 mL/g) are comparable, a potential source of toxicity is the glycerol contained in the material. We infer that some maturational change in the cell cortex occurs to enable the egg surface to furrow. Inhomogeneous barium-gelled alginate capsules without PLL are the optimal candidates for clinical trials, based on their enhanced biocompatibility and immune acceptance in vivo. It has typical clinical presentation and CT can provide clear delineation for diagnosis.

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We have determined the antitumor activity of MEN4901/T-0128, CPT-11, and T-2513 in BALB/cA Jcl nude mice bearing human gastric (H-81), colon (H-110), lung (Mqnu-1, H-74), esophageal (H-204), liver (H-181), and pancreatic (H-48) cancer lines, which had been serially transplanted s.c. Maternal cortisol and offspring birthweight: results from a large prospective cohort study. Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responses. It seems clear that parasitologists must return to first principles to solve how best to incorporate parasites into ecological food webs, and a first step in changing paradigms will be to include parasites in the classic ecological patterns that inform food web theory. However, these changes may simply reflect low birthweight in pre-eclampsia. coli isolates from calves and pigs with diarrhea or other diseases and from healthy animals. Analysis of the data according to the stepwise association model suggests that the dihydroxy bile salts associate to form dimers, trimers, and tetramers in addition to a larger aggregate which varies in size depending on the degree of conjugation of the bile salt.

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A contextual approach to psychotherapy, comprehensive distancing, which attempts to weaken dysfunctional verbal control is described briefly. The role of interleukin (IL)-17 in anxiety and depression of patients with rheumatoid arthritis. Moreover, truncation of the N-terminus to remove putative phosphorylation sites that might trigger autoinhibition did not confer functionality to AtYSL2. The impact of health care reform on employer costs: an analysis of the Massachusetts experience. This allows us (i) to understand qualitatively experimental and numerical results and (ii) to present a diagram mapping different possible impact dynamics for membrane systems, which accounts for the interplay between membrane tension, intrinsic modulus, and geometrical factors such as the frame size and the sphere radius. The patient made a good neurological recovery, and the postoperative positron emission tomographic scan demonstrated increases in both cerebral blood flow and cerebral metabolic rate of oxygen with a normalization of oxygen extraction fraction. Suggested shape for a first generation endovascular untethered microdevice prototype. The identified proteins representing several functions, mainly related to the glycolytic pathway, and metabolism of protein and lipid. Combining TURP and inguinal hernia repair in one session decreases the number of procedures and anesthesias, hospital stay, and thus direct health costs and does not result in an increase in operative or postoperative morbidity.

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Time-space sampling in minority communities: results with young Latino men who have sex with men. Five hundred and sixty-five spontaneous smiles and 15 spontaneous laughs (smiles accompanied by vocal sounds) were observed. Our aim was to determine the complex analysis of PAB, rPAB, GAB, antibodies against Saccharomyces cerevisiae, and perinuclear components of neutrophils in pediatric patients with IBD. on development of thermotolerance and thermochemosensitivity with BCNU in thermotolerant tumours, and on intratumoural pH alterations in previously unheated and thermotolerant tumours, was investigated in BT4An tumours grown on the hind foot of BD IX rats. These aromatic skeletons are detected selectively by REMPI-TOFMS. Our study supports the need to incorporate FISH profile test at initial work up in acute leukemia. 47 men in the HFRT arm were treated with 57 Gy in 17 fractions for 3.5 weeks, given as 13 fractions of 3 Gy plus four fractions of 4.5 Gy. However, the saturation of the surfactant effect is attained at lower surfactant concentrations than the polymer saturation point previously reported.

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Compounds from different classes differ both in mechanism of action and spectrum of antitumor activity. Episodes of fever were assessed according to standardized protocols. The main epidemiologic differences in the studies of perinatal asphyxia and hypoxic-ischemic encephalopathy are due to little agreement on their definition. The reliability of WBBPS as an initial diagnostic tool for VMs and AVM was assessed first by comparing its findings with matching MRI and/or duplex scan findings. In vitro and in vivo effects of promethazine (Phenergan) on drug metabolism. Serum levels of interleukin-18 and sICAM-1 in patients affected by breast cancer: preliminary considerations. Second resection and second resection with laminectomy were done. Nephroureterectomy has undergone critical changes during the past 15 years with the advent of the laparoscopic approach.

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Multivariate analysis demonstrated that menstrual status, number of involved lymph nodes, bc1-2, and p53 were significant predictors for overall survival, and that histological grade and number of nodes involved were significant predictors for disease-free survival. Theoretical analysis and examples are given to illustrate the theoretical results. Cervical epithelial leukocytes populations were (1) described in pregnancy, (2) observed over increasing gestation, (3) analysed in women who developed marked cervical shortening and (4) in those whose preterm labour recurred. Activation of kappa-opioid receptors on mossy fiber terminals in the hippocampus inhibits excitatory amino acid release. We characterized a population-based cohort of patients with secondary angiosarcomas from two tertiary hospitals to investigate this complication with respect to surgical treatment and outcome.

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This is despite a large, showy floral display and the dichogamous system of the species. Combined treatment with IH-901 and nonsteroidal anti-inflammatory drugs inhibited COX-2 enzyme and induced apoptosis in MDA-MB-231 and Hs578T cells. This article describes how one trust developed a training programme specifically for nurses to learn how to perform venepuncture and cannulation. At the Department of Oral and Maxillofacial Surgery, Kantonsspital Luzern, 20 patients with defects in the craniofacial and/or orbito-ethmoidal region have been treated using titanium micro-mesh between 1991 and 1998. At the University of Florida from January 1966 to March 1977, a total of 20 patients were treated whose first evidence of metastasis was a preauricular mass ranging in size from 1 to 6 cm. Increased contents of primary, secondary, intermediary and final products of lipid dilantin loading dose 1g peroxidation (LPO) in serum lipids as well as an intensified antioxidant activity were registered in children with erosive gastroduodenitis. The following results were obtained: (1) Plasma flows in the portal vein, hepatic artery and hepatic vein were significantly increased 20 min after growth hormone administration.

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Calcium structural transition of troponin in the complexes, on the thin filament, and in muscle fibres, as studied by site-directed spin-labelling EPR. In this method, it is necessary to make appropriate thermal distribution to the region of the brain tumor. Modified versions of this minimal gene set produced novel mono- and disaccharide avermectins. A 74-year-old man who had been institutionalized for severe multiinfarct dementia was found dead in bed. The thin film biosensor is an assay platform that can be formatted into a sensitive immunoassay for viral proteins in clinical specimens. Eight public middle schools in two distinct socio-economic areas of Jiangsu Province, China. Tranilast inhibits cardiac allograft vasculopathy in association with p21(Waf1/Cip1) expression on neointimal cells in murine cardiac transplantation model. Moreover protonix ec tablet crush , the substitution of plasma components like anti-idiotypic antibodies and immunoglobulins targeted against a host of antigens may add to its beneficial effects. The bone formed following distraction was stable and of good quality. Compression of the popliteal vein without arterial compression can be explained by the more lateral location of the popliteal vein relative to the artery and its proximity to the lateral head of the gastrocnemius.

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Sixty-two consecutive LSH were performed during this prospective study from March 2003 to March 2005 at Princess Royal University Hospital, Kent, UK. We also searched the trials register of the Cochrane Rehabilitation and Related Therapies Field. Joe Jelinski, Executive Director, Baton Rouge Technology Council. This process, defined as psychological selection, is strictly related to the quality of subjective experience. Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition. Identification of novel regions of allelic loss in ependymomas by high-resolution allelotyping with 384 microsatellite markers. Combined study of X-ray reflectivity and atomic force microscopy on a surface-grafted phospholipid monolayer on a solid.

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Vertebro-/Kyphoplasty as a percutaneous intervention should be considered for painful multisegmental disease and symptomatic osteolysis without epidural tumor compression to reach analgesia and stability. To document whether, how and when this topic is currently taught in U.K. It is therefore important to measure skin surface pH as precisely as possible. Combining the strengths of top-down lithography and bottom-up self-assembly using DNA nanostructures may provide a commercially viable route to fabricating electronic and photonic devices with nanometer-scale features. This insertion mutation in the RPGR exon ORF15 is associated with a RP phenotype that severely affects males early and females by 30 years of age, and is highly penetrant in female members. Little is known about the clonality of Staphylococcus epidermidis in the United States, although it is the predominant pathogen in infections involving prosthetic materials, including ventricular assist devices (VADs). Connotation of ecological integrity and its assessment methods: a review. The vast majority of foreign body aspirations occur in children less than 3 years of age, and the actual event of aspiration is frequently not witnessed. A high degree of polarization-conversion efficiency is achieved by a suitable choice of the grating length.

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Proliferative activity (Ki-67 labeling index) and expression of cell-cell adhesion associated molecules (E-cadherin, alpha-, beta-, and gamma-catenin, and p120) were examined using immunohistochemical techniques in 11 cases of sarcomatoid RCC. In stage I the cytoplasm is homogenous, in state II a perinuclear ring is formed, in stage III oocytes round bodies which are carbohydrate-protein complexes appear near the peripheri. CS are known to cause a variety of side effects and attempts have been made to reduce or eliminate their use through alternative methods such as phototherapy (UVA/UVB, UVA(1), UVB 311 nm). Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase. Equivalencies regarding the measurement and constructs of self-esteem and major life events in an Asian/Pacific islander sample. Keywords included intensive care, head injury, subarachnoid haemorrhage, status epilepticus, myasthenic crisis, Guillain-Barre syndrome and stroke. Tethering the Z ring to the membrane through a conserved membrane targeting sequence in FtsA. Deltamycins A1, A2, A3 and A4 which were active against Gram-positive bacteria were produced in organic complex media. Further studies with a larger sample size are needed to confirm these initial findings. KPC1 mutants that lack this region failed to mediate polyubiquitylation of p27 in vitro and expression of one such mutant delayed p27 degradation in vivo.

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Spiraling bubbles: how acoustic and hydrodynamic forces compete. Systemic conditions and treatments as risks for implant therapy. A novel series of competitive, reversible cathepsin S (CatS) inhibitors was discovered and optimized. Cytoplasmic ribonucleic acid (RNA) staining was increased by 24 hr, and by 48 hr the RNA formed globular masses, particularly in degenerating cells. Further assay of the nutritional requirements of the parasite appears to be hampered by the supply of nutrient furnished by the red cells and plasma. Adoption is uneven, and a technologic divide exists between physicians depending on their practice environment and mode of compensation. Combined abdominal and perineal approach for delayed restoration of bowel continuity after low anterior resection in females.

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